News & Views Essay Example | Topics and Well Written Essays - 1000 words

News & Views - Essay Example What is never mentioned, however, is that everybody has the right to read and get the most basic information about any disease including breast cancer. This news brief seeks to inform everyone that breast cancer is real, and with ever increasing research, the root cause hence the cure for the diases shall be known. Since it was rerpoted that breast cancer exists, a number of studies have sought to understand the its real cure. In most recent studies, it has been indicated that KLf8 to MMP14 signaling is the principle facilitator of metastasis of breast cancer (Lu et al, 2013). According to Lu et al KLf8 to MMP14 signaling helps in progression of breast cancer in human. Lu et al hinted that KLF8 also called the Kruppel-like factor 8, plays a significant role in regulating critical transcription gene, which is a gen responsible for causing cancer. However, what remains unclear is the conditions and mechanism of the operation of this gene. According to Lu et al, KLF8 facilitates the act ivity, rather than the matrix metalloproteinase expression. Background. The debate on the cause and treatment of breast cancer has never ceased. There is lacking scientific proof that breast care can be cured. The number of studies that have sought to ascertain the real cause of this deadly disease has always increased (Ara, & Deyama, 2000; Cristofanilli, 2006). However, most were focused on the initial stages of breast cancer. According to Nawrocki-Raby and Gilles (2003) metastatic cell can help increase the survival chances of a breast cancer patient. Symowicz and Adley (2007) noted that Kruppel-like factor 8 an important cancer promoting protein occurs in different categories of cancers. Zhao and Reiske (1998) KLF8 is one factor that targets the promoters of different oncogenes or the genes that suppress tumor for the transcriptional repression or activation. The function of KLF8 in breast cancer was identified, when KLFB was identified as a kinase focal adhesion downstream effec tor.KLF8is known to be overexpressed in the human cancers that are invasive, such as breast cancer, hence promoting the invasion of the breast cancer cells togehte rwith metastasis. This happens through the propulsion through cycle cell progression. Due to the valid functions of KLF8, the protein is always regulated at the post transitional and transitional levels together with the localization of the nuclear. From the conducted studies, there is no documented study that reports on the molecular mechanism signalling by KLF8 and known to facilitate breast cancer. IN metastasis, and tumor invasion the matrix metalloproteinase has a vital function to play. They operate downstream of FAK by enhancing tumor metastatis. Another study on this field identified MMP9 as one direct transcriptional target of activation by KLF8 together with the mediator promoting KLF8 breast cancer invasion of cell. Togehter with that finding, the study established that KLF8 can regulate the MMP2 3nzyme functio ns with no effect to the expressional levels. Explanation. For the invasiveness of breast cancer ceel, the KLF8 upregulation of MMP14 is vital. A study by Lu et al (2013) showed that the KLF8 overexpression in the cells of MCF-10 would facilitate the knockdown and invasion of the KLF8 inside the MDA-MB-231 invasion cells. This study found that MMP9 is a transcriptional target of activation of the KLF8 in the cells which take part in the invasion of KLF8 invasion dependent (Symowicz & Adley, 2007). The activity of MMP2 is reported to be upregulated